High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma

Table 3

Cox proportional regression analyses of variables affecting the distant metastasis-free survival (DMFS) in NPC patients.

Variables	Subsets	Distant metastasis-free survival
		Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
HLA-F expression	High vs. low and moderate	3.65 (1.53–8.73)	0.004	3.65 (1.53–8.73)	0.004
Gender	Male vs. female	0.90 (0.23–3.50)	0.882
Age (years)	<54 vs. ≥54	3.96 (0.84–18.66)	0.082
Tumour differentiation	Undifferentiated vs. differentiated	0.49 (0.10–2.31)	0.367
Tumour stage	T1 + T2 vs. T3 + T4	1.49 (0.42–5.35)	0.541
Lymph node status	N0 vs. N1–3	1.58 (0.33–7.43)	0.565
TNM stage	I + II vs. III + IV	4.81 (0.61–38.03)	0.136

Abbreviation: HR: hazard ratio; CI: confidence interval; HLA-F: human leukocyte antigen F; TNM: tumour node metastasis.