High HLA-F Expression Is a Poor Prognosis Factor in Patients with Nasopharyngeal Carcinoma

Table 4

Cox proportional regression analyses of variables affecting the overall survival (OS) in NPC patients.

Variables	Subsets	Overall survival
		Univariate analysis		Multivariate analysis
		HR (95% CI)	value	HR (95% CI)	value
HLA-F expression	High vs. low and moderate	1.76 (0.98–3.16)	0.059
Gender	Male vs. female	0.93 (0.38–2.27)	0.864
Age (years)	<54 vs. ≥54	2.03 (0.83–4.99)	0.122
Tumour differentiation	Undifferentiated vs. differentiated	0.69 (0.27–1.77)	0.443
Tumour stage	T1 + T2 vs. T3 + T4	2.21 (0.91–5.36)	0.080
Lymph node status	N0 vs. N1–3	1.90 (0.64–5.63)	0.250
TNM stage	I + II vs. III + IV	6.25 (1.45–27.01)	0.014	4.91 (1.11–21.82)	0.037
Local recurrence	No vs. yes	1.31 (0.38–4.44)	0.668
Distant metastasis	No vs. yes	4.34 (1.73–10.91)	0.002	3.84 (1.17–7.59)	0.022

Abbreviation: HR: hazard ratio; CI: confidence interval; HLA-F: human leukocyte antigen F; TNM: tumour node metastasis.