Table of Contents Author Guidelines Submit a Manuscript
Analytical Cellular Pathology
Volume 2018 (2018), Article ID 8651790, 8 pages
Research Article

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases

1Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Research and Service Centre for Occupational Safety, Finnish Institute of Occupational Health, Helsinki, Finland
3Department of Pathology, HUSLAB and Helsinki University Hospital, Helsinki, Finland
4Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Correspondence should be addressed to Harriet Wikman; ed.eku@namkiw.h

Received 31 August 2017; Accepted 23 January 2018; Published 10 April 2018

Academic Editor: Giovanni Tuccari

Copyright © 2018 Wladimir Gerstenberger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of 161 primary tumor samples. 50.7% of squamous cell lung cancer (SCC) tumors showed strong expression of CAV1 in the tumor-associated stromal cells, whereas only 15.1% of adenocarcinomas (AC) showed a strong CAV1 expression (). A strong CAV2 stromal expression was found in 46.0% of the lung tumor specimens, with no significant difference between the subtypes. Neither CAV1 nor CAV2 stromal expression was associated with any other clinicopathological factor including survival. When the stromal expression in matched primary tumors and lymph node metastases was compared, both CAV1 and CAV2 expressions were frequently found lost in the corresponding stroma of the lymph node metastasis (40.6%, and 38.4%, , resp.). Loss of stromal CAV2 in the lymph node metastases was also significantly associated with earlier death (). In conclusion, in contrast to the expression patterns in the tumor tissue of lung cancer, stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis.