Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features

Table 3

Clinicopathological characteristics in comparison to recurrence of early-stage adult granulosa cell tumors.

Features	All ()	Recurrent disease		value
		No ()	Yes ()
Age (years)
≤55 y	20 (56%)	18 (56%)	2 (50%)	1.00
>55 y	16 (44%)	14 (44%)	2 (50%)
FIGO substage
IA	30 (83%)	29 (91%)	1 (25%)	0.01
IC	6 (17%)	3 (9%)	3 (75%)
Surgery
Radical surgery	29 (81%)	28 (88%)	1 (25%)	0.018
Fertility surgery	7 (19%)	4 (12%)	3 (75%)
Tumor size
<10 cm	26 (77%)	23 (77%)	3 (75%)	1.00
≥10 cm	8 (23%)	7 (23%)	1 (25%)
Tumor gross appearance
Solid	21 (58%)	19 (59%)	2 (50%)	0.886
Cystic	6 (17%)	5 (16)	1 (25%)
Cystic-solid	9 (25%)	8 (25%)	1 (25%)
Growth patterns of AGCT
Only 1	6 (17%)	4 (13%)	2 (50%)	0.118
Mixed with 2 patterns	10 (28%)	10 (31%)	0
Mixed with 3 and more	20 (55%)	18 (56%)	2 (50%)
Dominant growth pattern AGCT
Diffuse	17 (47%)	13 (41%)	4 (100%)	0.004^±
Others	19 (53%)	19 (59%)	0
Grade of cytologic atypia
1	16 (44%)	16 (50%)	0	0.113
2 and 3	20 (56%)	16 (50%)	4 (100%)
Mitotic index
<4	19 (53%)	17 (53%)	2 (50%)	1.00
≥4	17 (47%)	15 (47%)	2 (50%)
LVSI
Negative	25 (69%)	24 (75%)	1 (25%)	0.075
Positive	11 (31%)	8 (25%)	3 (75%)
Necrosis
Absent	28 (78%)	25 (78%)	3 (75%)	1.00
Present	8 (22%)	7 (22%)	1 (25%)
Hemorrhage
Absent	26 (72%)	25 (78%)	1 (25%)	0.056
Present	10 (28%)	7 (22%)	3 (75%)
Prominent fibrothecomatous component
Absent	23 (64%)	21 (66%)	2 (50%)	0.609
Present	13 (36%)	11 (34%)	2 (50%)

Fisher exact test; chi-squared test; AGCT: adult granulosa cell tumor; LVSI: lymphovascular space invasion.