Analytical Cellular Pathology / 2018 / Article / Tab 3

Research Article

Adult Granulosa Cell Tumors of the Ovary: A Retrospective Study of 36 FIGO Stage I Cases with Emphasis on Prognostic Pathohistological Features

Table 3

Clinicopathological characteristics in comparison to recurrence of early-stage adult granulosa cell tumors.

FeaturesAll ()Recurrent disease value
No ()Yes ()

Age (years)
 ≤55 y20 (56%)18 (56%)2 (50%)1.00
 >55 y16 (44%)14 (44%)2 (50%)
FIGO substage
 IA30 (83%)29 (91%)1 (25%)0.01
 IC6 (17%)3 (9%)3 (75%)
Surgery
 Radical surgery29 (81%)28 (88%)1 (25%)0.018
 Fertility surgery7 (19%)4 (12%)3 (75%)
Tumor size
 <10 cm26 (77%)23 (77%)3 (75%)1.00
 ≥10 cm8 (23%)7 (23%)1 (25%)
Tumor gross appearance
 Solid21 (58%)19 (59%)2 (50%)0.886
 Cystic6 (17%)5 (16)1 (25%)
 Cystic-solid9 (25%)8 (25%)1 (25%)
Growth patterns of AGCT
 Only 16 (17%)4 (13%)2 (50%)0.118
 Mixed with 2 patterns10 (28%)10 (31%)0
 Mixed with 3 and more20 (55%)18 (56%)2 (50%)
Dominant growth pattern AGCT
 Diffuse17 (47%)13 (41%)4 (100%)0.004±
 Others19 (53%)19 (59%)0
Grade of cytologic atypia
 116 (44%)16 (50%)00.113
 2 and 320 (56%)16 (50%)4 (100%)
Mitotic index
 <419 (53%)17 (53%)2 (50%)1.00
 ≥417 (47%)15 (47%)2 (50%)
LVSI
 Negative25 (69%)24 (75%)1 (25%)0.075
 Positive11 (31%)8 (25%)3 (75%)
Necrosis
 Absent28 (78%)25 (78%)3 (75%)1.00
 Present8 (22%)7 (22%)1 (25%)
Hemorrhage
 Absent26 (72%)25 (78%)1 (25%)0.056
 Present10 (28%)7 (22%)3 (75%)
Prominent fibrothecomatous component
 Absent23 (64%)21 (66%)2 (50%)0.609
 Present13 (36%)11 (34%)2 (50%)

Fisher exact test; chi-squared test; AGCT: adult granulosa cell tumor; LVSI: lymphovascular space invasion.

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