GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer

<div>An interaction network of the DEGs in cell cycle and detection of the effect of GTSE1 knockdown on the cell cycle distribution. (a) An interaction network of DEGs related to cell cycle regulation. Red represented DEGs detected in microarray analysis including TGF<i>β</i>, Ink4d, CycE, CDK2, Cip1, Mdm2, GADD45, PCNA, MCM (Mcm6), ATMATF, 14-3-3, and Cdc20. (b) Normalized expression level and fold change of 6 DEGs distributed in S phase in shGTSE1 cells. NC: negative control. (c, d) FACS-based DNA content analysis was used to explore the effect of GTSE1 knockdown on the cell cycle profiles of Bel-7404 cells. The percentage of cells in G1, S, and G2/M phases is shown. 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Analytical Cellular Pathology

fig4

Figure 4

Figure 4: GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer 