Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma

Figure 5

Schematic overview of the folate metabolic pathway mediated by FOLR, DHFR, and MTRR. Arrows that cross the line indicate metabolites that can travel between compartments. FOLR1: folate receptor 1; DHFR: dihydrofolate reductase; MTRR: methionine synthase reductase; MTR: methionine synthase; FH4: tetrahydrofolate; 5,10-CH2-FH4: 5,10-methylenetetrahydrofolate; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; Hcy; homocysteine; MTHFD: methylenetetrahydrofolate dehydrogenase; GART: phosphoribosylglycinamide formyltransferase; DNMTs: DNA methyltransferases.