Research Article
Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma
Table 2
Correlation between FOLR1, DHFR, and MTRR expression and clinicopathological parameters.
| Parameters | Total | FOLR expression | | DHFR expression | | MTRR expression | |
| Histology | Epithelial | 61 | | 0.001 | | 0.543 | | 0.001 | Other | 19 | | | |
| FIGO Stage | I-II | 37 | | 0.004 | | 0.360 | | 0.036 | III-IV | 43 | | | |
| Grade | G1 | 30 | | 0.006 | | 0.123 | | 0.033 | G2-G3 | 50 | | | |
| Node status | Positive | 23 | | 0.026 | | 0.149 | | 0.048 | Negative | 57 | | | |
| Omentum metastasis | Yes | 28 | | 0.584 | | 0.044 | | 0.734 | No | 52 | | | |
| Organ metastasis | Yes | 20 | | 0.015 | | 0.169 | | 0.032 | No | 60 | | | |
| Ascites | ≥500 ml | 30 | | 0.367 | | 0.087 | | 0.227 | <500 ml | 50 | | | |
| Platinum resistance | Resistant | 28 | | 0.004 | | 0.014 | | 0.015 | Sensitive | 52 | | | |
| Outcome | CR | 27 | | 0.001 | | 0.032 | | 0.047 | PR | 25 | | | | SD | 12 | | | | PD | 16 | | | |
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Notes: : metastasis to any one of liver, lung, brain and spleen. |