Current Research Progress on Long Noncoding RNAs Associated with Hepatocellular Carcinoma

Table 1

Dysregulated long noncoding RNAs (lncRNAs) associated with HCC.

LncRNAs	Expression	Affected target genes and pathways	Affected clinicopathological characteristics of HCC	References
HOTAIR	Upregulated	HOXD/VEGF/MMP-9/PRC2/H3K27/rbm38/Bmi-1/P14/P16	TNM stage, distant metastasis	[31–34]
HULC	Upregulated	P18/PRKACB/CREB	TNM stage, intrahepatic metastases	[38, 39, 54]
H19	Upregulated	Cdc25A/E2F1/hnRNP U/PCAF/DMC/ZEB1/2		[51, 55]
URHC	Upregulated	ZAK	Tumor size, tumor number	[9]
ROR	Upregulated	TGF-β/PDK1/P53		[56]
PVT1	Upregulated	TGF-β/NOP2	AFP level, tumor size, tumor number, tumor stage	[14, 57]
PTTG3P	Upregulated	PPTG1/AKT signalling	Tumor size, TNM stage	[43]
XIST	Upregulated	miR-139-5p/PDK1/AKT signalling	Tumor size	[26]
DBH-AS1	Upregulated	P53/ERK/MAPK signalling	HBsAg, tumor size	[58]
MEG3	Downregulated	UHRF1/P53	Tumor size, Edmondson grade	[47, 59]
DREH	Downregulated	HBx/vimentin	Tumor size, HBsAg	[48, 49]
PTENP1	Downregulated	miR-17/miR-19b/miR-20a/AKT/PI3K signalling	Tumor size, TNM stage	[60]
LET	Downregulated	P53/NF90/HIF-1α		[50]
uc002mbe.2	Downregulated	TAS	Tumor size	[52]