Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?

Figure 4

Supersonic share wave elasticity images and HE- and MT-stained liver sections in rabbit models of NAFLD. (a) From a normal rabbit liver. Share wave elasticity image shows that the Emean value was 5.7 kPa. Liver sections show normal histologic performances without steatosis, ballooning degeneration, inflammation, and fibrosis. (b) From a rabbit liver with SS. The Emean value was 8.2 kPa. Liver sections show hepatic steatosis without ballooning degeneration, inflammation, and fibrosis. (c) From a borderline rabbit liver. The Emean value was 9.5 kPa. Liver sections show dispersive hepatic steatosis with sporadic ballooning degeneration, and no significant inflammation and fibrosis can be found. (d) From a rabbit liver with NASH. The Emean value was 12.9 kPa. Liver sections show diffuse hepatic steatosis with sporadic ballooning degeneration and inflammation, without fibrosis. (e) From a rabbit liver with NASH. The Emean value was 15.1 kPa. Liver sections show dispersive hepatic steatosis with significant ballooning degeneration and hyperplasia of perisinusoidal fibrous tissue. HE: hematoxylin-eosin; MT: Masson’s trichrome; NAFLD: nonalcoholic fatty liver disease; Emean: mean elasticity value; SS: simple steatosis; NASH: nonalcoholic steatohepatitis.

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