Table 3: Correlation between COX-2 immunostaining and clinicopathological features of UCB.

ParameterCOX-2 immunostaining value
LowHigh

SexMale85170.793
Female174

Age<60 years4160.320
≥60 years6115

GradeLow grade3010.013
High grade7220

Muscle invasionNegative4020.017
Positive5819
Indeterminate40

Pathological stage (pT)pT14420.003
pT25819
pT3
pT4

Nodal metastasisNegative85130.08
Positive178

Distant metastasisNegative100100.031
Positive211

Lymphovascular invasionNegative9740.008
Positive517

Anatomical stageI4120.015
II6119
III
IV

Local disease recurrenceNegative69140.931
Positive337

SurvivalAlive71160.548
Dead315

Kruskal-Wallis test; Mann-Whitney test; T1: tumor invades subepithelial connective tissue; T2: tumor invades muscularis propria; T3: tumor invades perivesical tissue; T4: tumor invades any of the following: prostatic stroma, seminal vesicles, uterus, vagina, pelvic wall, or abdominal wall; stage I: T1, N0, and M0; stage II: T2, N0, and M0; stage III: T3 or T4a, N0, and M0; stage IV: any T and N1-3 or M1.