Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice

Table 2

Histological scoring scheme for chemically induced colonic inflammation in chronic model [23].

Inflammatory cell infiltration (score 1)			Intestinal architecture (score 2)
Severity	Extent	Score value	Epithelial changes	Mucosal architecture	Score value
Normal	Normal cellularity	0	Intact or normal	Normal	0
Minimal	Mucosa	1	Minimal hyperplasia	—	1
Mild	Mucosa, sometimes extending into submucosa	2	Mild hyperplasia, minimal goblet cell loss ± erosions		2
Moderate	Mucosa and submucosa	3	Moderate hyperplasia ± moderate goblet cell loss ± erosions	± Focal ulcerations	3
Marked	Mucosa and submucosa	4	Marked hyperplasia	± Irregular crypts or crypt loss ± ulcerations	4
Marked	Transmural	5	Marked hyperplasia ± multiple crypt abscesses	± Irregular crypts or crypt loss ± ulcerations	5

Sum of scores 1 and 2: a range of 0-10.