Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Table 2

Comparison of the laboratory parameters and echocardiographic variables between the two groups.

Parameters	AECOPD group ()	PH group ()	value
WBC (×10^9/l)	7.72 (5.83-9.99)	7.90 (6.79-10.41)	0.432
RBC (×10^12/l)			0.751
Hemoglobin (g/l)			0.586
Neutrophils (×10^9/l)	5.75 (4.18-7.89)	6.26 (4.85-8.17)	0.063
Lymphocytes (×10^9/l)	1.24 (0.95-1.59)	0.91 (0.66-1.26)
Monocytes (×10^9/l)	0.52 (0.38-0.68)	0.54 (0.41-0.72)	0.576
Platelets (×10^9/l)	201.50 (165.00-252.50)	193.00 (154.00-229.00)	0.202
NLR	4.08 (2.89-7.26)	6.52 (4.95-12.28)
PLR	156.71 (123.50-227.21)	220.88 (161.08-290.91)
SII	884.87 (554.77-1453.34)	1453.38 (952.45-2441.84)
Albumin (g/l)			0.003
NT-proBNP (pg/ml)	133.00 (76.00-238.50)	653.00 (167.00-1565.00)
PH			0.080
PaCO2 (mmHg)	44.35 (40.90-50.00)	50.10 (42.30-61.90)	0.002
HCO3^- (mmol/l)	28.60 (26.90-31.20)	31.50 (27.30-37.40)	0.002
Lac (mmol/l)	1.50 (1.00-1.80)	1.60 (1.20-2.10)	0.032
D-Dimer (μg/ml)	0.39 (0.28-0.60)	0.65 (0.37-1.38)
Fibrinogen (g/l)	4.30 (3.49-5.32)	4.26 (3.32-6.17)	0.708
LAD (mm)	27 (26-29)	29 (24-31.5)	0.217
LVDD (mm)			0.254
RAD (mm)
RVD (mm)	17 (16-18)	18 (17-20)	0.020
LVEF	68 (66-68)	68 (65-68)	0.296

Abbreviations: AECOPD—acute exacerbation of chronic obstructive pulmonary disease; PH—pulmonary hypertension; WBC—white blood cell; RBC—red blood cell; NLR—neutrophil-to-lymphocyte ratio; PLR—platelet-to-lymphocyte ratio; SII—systemic-immune-inflammation index; PaCO₂—partial pressure of carbon dioxide; HCO₃^-—bicarbonate ion; Lac—lactic acid; LAD—left atrium diameter; LVDD—left ventricular end diastolic diameter; RAD—right atrium diameter; RVD—right ventricular diameter; LVEF—left ventricular ejection fraction.