Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Table 3
Laboratory parameters and echocardiographic variables based on severity of PH.
Mild PH ()
Moderate PH ()
Severe PH ()
value
Lym (×109/l)
b
c
b,c
0.009
NLR
6.07 (4.86-11.25)
6.29 (5.05-10.62)
7.73 (4.80-17.73)
0.372
PLR
210.64 (153.61-277.05)b
210.31 (160.63-263.37)c
326.59 (232.77-443.02)b,c
0.010
SII
1473.25 (813.27-2448.08)
1299.09 (932.72-2352.89)
1611.04 (1047.50-2999.36)
0.432
Albumin (g/l)
37.85 (34.65-41)
36.10 (32.60-39.35)
35.40 (33.43-36.85)
0.158
NT-proBNP (pg/ml)
237.50 (108-1050.25)a,b
887 (274-3296)a
1588 (587-5296)b
PaCO2 (mmHg)
45.70 (39.25,51.38)a
60.10 (49.55-72.05)a
56.55 (40.85-63.78)
HCO3- (mmol/l)
28.30 (26.70-32.20)a,b
36.30 (32-40.60)a
35.55 (28.13-39.43)b
Lac (mmol/l)
0.389
D-Dimer (μg/ml)
0.52 (0.37-0.94)
0.93 (0.39-2.30)
1.15 (0.38-1.73)
0.099
LAD (mm)
0.114
LVDD (mm)
43 (40-47)
45 (41-47)
42 (35-46.25)
0.190
RAD (mm)
a,b
a
b
RVD (mm)
17 (16-18)a,b
19 (17-22)a
20.5 (17-32.5)b
PTRV (m/s)
2.9 (2.81-3.06)a,b
3.47 (3.33-3.64)a,c
4.31 (4.06-4.88)b,c
PASP (mmHg)
a,b
a,c
b,c
LVEF
68 (65-68)
67 (65-68)
66 (65-68)
0.254
Abbreviations: Lym—lymphocytes; NLR—neutrophil-to-lymphocyte ratio; PLR—platelet-to-lymphocyte ratio; SII—systemic-immune-inflammation index; PaCO2—partial pressure of carbon dioxide; HCO3-—bicarbonate ion; Lac—lactic acid; LAD—left atrium diameter; LVDD—left ventricular end diastolic diameter; RAD—right atrium diameter; RVD—right ventricular diameter; PTRV—peak tricuspid regurgitation velocity; PASP—pulmonary artery systolic pressure; LVEF—left ventricular ejection fraction. a for mild PH vs. moderate PH; b for mild PH vs. severe PH; c for moderate PH vs. severe PH.
