Research Article
Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Table 5
Univariate and multivariate analysis of the effects of the baseline parameters on PH.
| | Factors | Univariate analysis | Multivariate analysis | | OR (95% CI) | value | OR (95% CI) | value |
| | Lymphocyte (109/l) | 0.226 (0.114, 0.448) | <0.001 | 1.055 (0.273, 4.078) | 0.938 | | NLR | 1.173 (1.081, 1.273) | <0.001 | 1.161 (0.924, 1.458) | 0.200 | | PLR | 1.006 (1.003, 1.009) | <0.001 | 1.003 (0.993, 1.013) | 0.564 | | SII | 1.001 (1.000, 1.001) | <0.001 | 0.999 (0.998, 1.001) | 0.256 | | NT-proBNP (pg/ml) | 1.003 (1.001, 1.004) | <0.001 | 1.002 (1.001, 1.003) | <0.001 | | PaCO2 (mmHg) | 1.047 (1.019, 1.075) | <0.001 | 1.018 (0.939, 1.104) | 0.664 | | HCO3- (mmol/l) | 1.103 (1.042, 1.167) | <0.001 | 0.981 (0.822, 1.170) | 0.828 | | Lac (mmol/l) | 1.911 (1.130, 3.234) | 0.016 | 1.663 (0.837, 3.305) | 0.146 | | D-Dimer (μg/ml) | 1.910 (1.235, 2.953) | 0.0036 | 1.581 (0.960, 2.603) | 0.072 |
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Abbreviations: PH—pulmonary hypertension; PaCO2—partial pressure of carbon dioxide; HCO3-—bicarbonate ion; NLR—neutrophil-to-lymphocyte ratio; PLR—platelet-to-lymphocyte ratio; SII—systemic-immune-inflammation index; Lac—lactic acid; CI—confidence intervals; OR—odds ratio.
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