Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Table 6

Comparison of the discriminative ability of NLR, PLR, SII, and NT-proBNP to predict PH.

Parameters	NLR	PLR	SII	NT-proBNP
Cut-off value	4.659	160.0	1012	384.0
AUC	0.701	0.669	0.670	0.776
95% CI	0.629, 0.766	0.596, 0.736	0.597, 0.737	0.709, 0.834
Sensitivity (%)	81.2	77.2	70.3	58.4
Specificity (%)	59.5	53.6	59.5	92.9
Positive predictive value (%)	70.7	66.7	67.6	90.8
Negative predictive value (%)	72.5	66.2	62.5	65.0
Accuracy (%)	71.4	66.5	65.4	74.1
Associated criterion	0.407	0.308	0.298	0.513
	181	108	167	128

Abbreviations: NLR—neutrophil-to-lymphocyte ratio; PLR—platelet-to-lymphocyte ratio; SII—systemic-immune-inflammation index; AUC—area under the curve; CI—confidence interval.