Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Figure 2

LPS decreased renal α-klotho expression (a–d). Mouse heart and kidney tissues were collected from the control group (). Real-time PCR and western blotting analysis showing the expression of α-klotho mRNA (a) and protein (b) levels in the control’s hearts and kidneys. Mouse kidney samples were collected at 0 h, 6 h, and 24 h after LPS (10 mg/kg) injection in the LPS group (). Real-time PCR and western blotting analysis showing the expression of α-klotho mRNA (c) and protein (d) levels in mouse kidneys. .

(a)

(b)

(c)

(d)