The Effect of Protein FAM172A on Proliferation in HepG2 Cells and Investigation of the Possible Molecular Mechanism

Figure 3

FAM172A-1 recombinant protein activated MAPK/ERK and PI3K/Akt pathways in HepG2 cells. After being serum-starved for 24 h, HepG2 cells were treated with FAM172A-1 recombinant protein (100 ng/mL) for 0 h, 4 h, 8 h, and 12 h. Western blot analysis showed that the level of ERK1/2 and Akt phosphorylation was significantly increased after treatment with FAM172A-1 while the level of total ERK1/2 and Akt remained unchanged.