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Analytical Cellular Pathology
Volume 2019, Article ID 8079368, 5 pages
https://doi.org/10.1155/2019/8079368
Research Article

Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis

1Tyumen State Medical University, Tyumen, Russia
2Tyumen Scientific Centre, Tyumen, Russia
3Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russia
4Sechenov University, Moscow, Russia
5Russian Medical Academy of Continuing Professional Education, Moscow, Russia

Correspondence should be addressed to Evgeny N. Morozov; ur.liam@vozorome

Received 31 December 2018; Revised 20 May 2019; Accepted 10 June 2019; Published 24 July 2019

Guest Editor: Zhigang Ren

Copyright © 2019 Vitaly G. Bychkov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. The smallest changes in the infestation intensity indicators and egg production were observed in the experimental stomach tumours (). A partial hepatectomy in the setting of opisthorchiasis did not affect the number of parasites in the ecological niche (liver) or the production of eggs by the helminth. With the deterioration of the vegetation state, parasite clumps of opisthorchii increase egg production under the conditions of distress.