Destruction of the Dorsal Motor Nucleus of the Vagus Aggravates Inflammation and Injury from Acid-Induced Acute Esophagitis in a Rat Model

Figure 3

Esophageal instillation and DMV destruction led to severe esophageal tissue damage in rats. (a) HE staining of the lower esophagus in the control group (Con), sham + saline group (S+S), sham + acid group (S+A), operation + saline group (O+S), and operation + acid group (O+A). Arrows shows submucosal edema. (b) The esophageal tissue damage scores under the light microscope in rats in the acute esophagitis model induced by esophageal instillation and DMV destruction (, and ). The microscopic esophagitis scores in the lower esophageal segment were significantly higher in the sham + acid group than in the sham + saline group () (). No significant difference in the microscopic esophagitis scores was observed between the operation + saline group () and the sham + acid group () (). The microscopic esophagitis scores were higher in the lower esophageal segment of the operation + acid group () than in the operation + saline group ().

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