Destruction of the Dorsal Motor Nucleus of the Vagus Aggravates Inflammation and Injury from Acid-Induced Acute Esophagitis in a Rat Model

Figure 4

Esophageal instillation and DMV destruction caused activation of NF-κB in esophageal tissue of rats. (a) NF-κB p65-positive cells with dark brown nuclei in the esophagus of all animals. Con: control group (×400); S+S: sham + saline group (×400); S+A: sham + acid group (×400); O+S: operation + saline group (×400); O+A: operation + acid group (×400). (b) The activation of NF-κB p65 in the lower esophageal segment increased more significantly in the operation + acid group than in the operation + saline group (). No significant difference in the NF-κB p65 activation in the esophagus was observed between the operation + saline group and the sham + acid group (). In the control and sham + saline rats, NF-κB p65 activation was not observed (, ).

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