The State of the Art on Blood MicroRNAs in Pancreatic Ductal Adenocarcinoma

Table 1

MicroRNAs for the early detection of pancreatic cancer.

MicroRNAs	Function	Expression	Targets	Reference
miR-21	Oncogenic	↑	PI3K/AKT/PTEN, PDCD4, and Bcl-2/FasL	[16–20]
	Suppresses apoptosis and promotes proliferation
miR-196a	Oncogenic	↑	—	[20]
miR-34	Tumor suppressor	↓	Bcl-2/Notch	[21, 22]
	Inhibits proliferation, invasion, and induces apoptosis
miR-200	Tumor suppressor	↓	Notch, E-cadherin, and ZEB	[23]
Let-7	Tumor suppressor	↓	N-cadherin/ZEB1	[23]
	Reverses EMT and inhibits invasion
miR-221	Oncogenic	↑	PI3K/AKT/PTEN, MMP-2, and MMP-9	[19, 24]
	Cancer cell invasion
miR-145	Tumor suppressor	↓	KRAS	[25]
	Inhibits tumor growth
miR-155	Oncogenic	↑	TP53INP	[26]
miR-15a	Tumor suppressor	↓	WANT3A, FGF7, and BMI-1	[27]
	Inhibits proliferation and EMT
miR-506	Tumor suppressor	↓	SPHK1, PI3M	[28, 29]
	Inhibits proliferation and induces apoptosis
miR-96	Tumor suppressor	↓	KRAS, AKT	[30]
	Inhibits proliferation and invasion and induces apoptosis
miR-29a	Oncogenic	↑	Wnt/β-catenin	[31]