Analytical Cellular Pathology

Review Article

The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma

Table 1

Summary of the roles of MMPs involved in the EMT of HCC and their interactions.
MMPCategoryRole in the EMT of HCCCross-activated by MMPReferences
MMP-1CollagenaseInvasion and metastasisMMP-3, MMP-7, and MMP-10[21, 25, 43, 44]
MMP-2GelatinaseInvasion and metastasisMMP-1, MMP-7, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, MMP-17, MMP-24, and MMP-25[22–26, 44–46]
MMP-3StromelysinInvasion and metastasisMMP-12[47–60, 74]
MMP-7MatrilysinInvasion and metastasisMMP-3, MMP-10[21, 50, 51]
MMP-8CollagenaseAngiogenesis and migrationMMP-3, MMP-10[21, 52–54]
MMP-9GelatinaseAngiogenesis, invasion, and metastasisMMP-2, MMP-3, MMP-7, MMP-10, and MMP-13[21, 24, 55–58, 74]
MMP-10StromelysinAngiogenesis, invasion, and metastasisN/A[59–62]
MMP-11StromelysinInvasion and metastasisN/A[63, 64]
MMP-13CollagenaseInvasion and metastasisMMP-2, MMP-3, MMP-7, MMP-10, MMP-14, and MMP-15[22, 25, 26, 65, 66]
MMP-14Membrane-typeInvasion and metastasisMMP-14[22, 67, 68]
MMP-16Membrane-typeInvasion and metastasisN/A[40, 69]
MMP-26MatrilysinInvasion and metastasisMMP-26[25, 70, 71]
MMP-28OtherInvasion and metastasisN/A[72, 73]