The Role of Rho GTPases in VEGF Signaling in Cancer Cells

Figure 1

VEGF expression is regulated by Rho GTPases in cancer cells. RhoA, RhoC, and PI3K are involved in VEGF expression in cancer cells leading to angiogenesis and migration. Downregulation of VEGF during hypoxia is due to the overexpression of StarD13 (Rho GAP) which inhibits the activity of Rho A, RhoC, and PI3K.