The Role of Rho GTPases in VEGF Signaling in Cancer Cells

Figure 2

VEGF stimulates angiogenesis in endothelial cells in a Rho GTPase-dependent manner. The VEGFA/VEGF2 axis stimulates the activation of RhoA, Cdc42, and Rac1 leading to vascular development and formation of cytoplasmic migratory structures. Our lab has further proven that RhoG is a positive regulator of angiogenesis in vascular endothelial cells.