Association of JMJD2B and Hypoxia-Inducible Factor 1 Expressions with Poor Prognosis in Osteosarcoma

Table 3

Univariate Cox proportional regression analysis for the association of clinicopathological factors with overall survival of OS patients.

Characteristics			HR	OS
				95% CI
Gender	Female	23	1		0.214
	Male	30	0.677	0.366-1.252
Age	<20 years	22	1		0.865
	≥20 years	31	0.948	0.511-1.759
Tumor size	<5 cm	24	1		0.492
	≥5 cm	29	1.240	0.671-2.291
Histologic grade	Well differentiated	18	1		0.988
	Moderately differentiated	19	0.998	0.478-2.080
	Poorly differentiated	16	1.053	0.499-1.053
Distant metastasis	No	30	1		<0.001
	Yes	23	5.311	2.403-11.736
Neoadjuvant chemotherapy	Yes	32	1		0.002
	No	21	3.118	1.522-6.389
Enneking stage	I	10	1		<0.001
	II	9	12.605	2.643-60.109
	III	25	51.909	9.949-270.831
HIF1	Low	9	1		<0.001
	Moderate	15	10.589	2.230-50.275
	High	29	44.344	8.280-237.493
JMJD2B	Low	7	1		<0.001
	Moderate	18	20.018	2.470-162.224
	High	28	110.895	11.857-1037.165

OS: overall survival; HR: hazard ratio; 95% CI: 95% confidence interval. .