Expression of Tight Junction Proteins Is Altered in Bladder Cancer
Table 1
Correlation between claudin-4, ZO-1, and ZONAB expressions and clinicopathological factors of bladder cancer detected by immunohistochemical test.
Index
High expression
Claudin-4 (%)
ZO-1 (%)
ZONAB (%)
Gender
Male
42
18 (42.9)
0.880
25 (59.5)
0.808
16 (38.1)
0.918
Female
11
5 (45.5)
7 (63.6)
4 (36.4)
Age (years)
>65
36
15 (41.7)
0.718
22 (61.1)
0.877
11 (30.6)
0.121
≤65
17
8 (47.1)
10 (58.8)
9 (52.9)
Muscle invasion
+
23
11 (47.8)
0.578
10 (43.5)
0.028a
14 (60.9)
0.002b
−
30
12 (40.0)
22 (73.3)
6 (20.0)
Lymph node metastasis
+
9
2 (22.2)
0.166
4 (44.4)
0.292
2 (22.2)
0.301
−
44
21 (47.7)
28 (63.6)
18 (40.9)
Distant metastasis
+
3
1 (33.3)
0.412
2 (66.7)
0.823
1 (33.3)
0.874
−
50
22 (44.0)
30 (60.0)
19 (38.0)
aSpearman’s rank order correlation coefficient: -0.303; there is a negative correlation ().bSpearman’s rank order correlation coefficient: 0.418; there is a positive correlation ().
