Metformin: A Possible Option in Cancer Chemotherapy

Figure 1

Mechanisms of antineoplastic action of metformin. MOA: mechanism of action; ADORA1: adenosine A1 receptor; AMPK: adenosine monophosphate kinase: ROS: reactive oxygen species; mTORC1: mammalian target of rapamycin complex 1; IGF: insulin-like growth factor; ↓: inhibition; ↑: activation.