Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas

Figure 5

EGFR posttranslational regulators MDGI, MIG6, and EIG121 signalling pathways. EGF binding causes ligand-receptor complex to internalize via clathrin. Liganded EGFR monomers dimerize and translocate along the plasma membrane until association with a membrane domain that is enriched with clathrin on the intracellular face. This domain invaginates to initiate a clathrin-coated pit, which pinches off to form a clathrin-coated vesicle. Clathrin is shed from this primary vesicle to produce an intermediate vesicle that fuses with and delivers EGF/EGFR complex to an early endosome. The early endosome then matures into a late endosome and delivers cargo to lysosome.