Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas

Table 1

MDGI, MIG6, EIG121, and EGFR mRNA expression by RT-PCR in breast tumors ().

Genes	mRNA	All tumors; <0.5 >2	HR-/HER2- (TNC); <0.5 >2	HR-/HER2+; <0.5 >2	HR+/HER2-; <0.5 >2	HR+/HER2+; <0.5 > 2	value
MDGI	Status	25.7% 61.6% 12.7%	33.3% 58.8% 7.9%	23.9% 71.8% 4.3%	26.0% 59.4% 14.6%	16.0% 68.0% 16.0%	0.14 (NS)
	Level	0.76 (0.14-26.84)	0.62 (0.15-26.84)	0.83 (0.20-4.78)	0.75 (0.14-18.16)	0.96 (0.29-7.73)
MIG6	Status	45.0% 49.5% 5.5%	28.6% 65.1% 6.3%	32.6% 50.0% 17.4%	51.2% 44.9% 3.9%	42.0% 56% 2.0%	0.0001
	Level	0.53 (0.00-5.93)	0.71 (0.08-3.96)	0.66 (0.13-5.93)	0.49 (0.00-5.34)	0.54 (0.00-3.86)
EIG121	Status	16.1% 61.6% 22.3%	60.3% 31.8% 7.9%	13.0% 74.0% 13.0%	7.5% 66.9% 25.6%	12.0% 58.0% 30.0%	<0.0001
	Level	1.19 (0.00-15.73)	0.33 (0.00-4.53)	0.93 (0.21-4.41)	1.36 (0.08-15.73)	1.49 (0.23-6.65)
EGFR	Status	84.8% 13.8% 1.4%	63.5% 30.2% 6.3%	69.6% 30.4% 0.0%	91.5% 8.1% 0.4%	88% 10.0% 2.0%
	Level	0.16 (0.01-82.84)	0.44 (0.03-82.84)	0.20 (0.04-1.67)	0.13 (0.01-7.30)	0.15 (0.03-2.58)

Chi-squared test: total value ().