Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas

Table 2

MDGI, MIG6, EIG121, and EGFR protein expression by IHC in breast tumors ().

Protein	All tumors; 0 1 2/3	HR-/HER2- (TNC); 0 1 2/3	HR-/HER2+; 0 1 2/3	HR+/HER2-; 0 1 2/3	HR+/HER2+; 0 1 2/3	value
MDGI	19.4% 67% 13.6%	27.7% 66.6% 5.7%	10% 70% 20%	19.1% 68% 12.9%	15.3% 61.7% 23%	0.77 (NS)
MIG6	43.2% 46.6% 10.2%	22.2% 61.1% 16.7%	30% 60% 10%	55.3% 38.2% 6.5%	38.4% 46.3% 15.3%	0.27 (NS)
EIG121	19.4% 57.9% 22.7%	61.1% 33.3% 5.6%	20% 70% 10%	6.3% 63.8% 29.9%	7% 61.5% 31.5%	<0.0001
EGFR	59.1% 26.1% 14.8%	27.7% 0% 72.3%	40% 60% 0%	76.5% 23.5% 0%	53.0% 47.0% 0%

Chi squared test: total value (). IHC score 0: underexpression; score 1: normal expression; score 2/3: overexpression.