Research Article
Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma
Table 1
Correlations of DSG1 and DSG2 protein expression with the clinicopathological characteristics of EHCC.
| CPC | Case no. | DSG1 | DSG2 | Pos No. (%) | | value | Pos No. (%) | | Value |
| Age (year) | | | | | | | | ≤45 years | 17 | 8 (47.1) | 0.215 | 0.643 | 9 (52.9) | 0.290 | 0.590 | >45 years | 83 | 34 (41.0) | 38 (45.8) | Sex | | | | | | | | Male | 61 | 27 (44.3) | 0.329 | 0.566 | 29 (47.5) | 0.018 | 0.892 | Female | 39 | 15 (38.5) | 18 (46.2) | Differentiation | | | | | | | | Well | 31 | 24 (77.4) | 23.142 | 0.000 | 25 (80.6) | 6.434 | 0.040 | Moderately | 34 | 9 (26.5) | | | 11 (32.4) | | | Poorly | 35 | 9 (25.7) | | | 11 (31.4) | | | Tumour size | | | | | | | | ≤3 cm | 62 | 27 (43.5) | 0.161 | 0.689 | 29 (46.8) | 0.003 | 0.954 | >3 cm | 38 | 15 (39.5) | | | 18 (47.4) | | | Tumour position | | | | | | | | Hilar site | 27 | 10 (37.0) | 0.990 | 0.609 | 12 (44.4) | 0.991 | 0.609 | Hepatic duct | 4 | 1 (25.0) | | | 1 (25.0) | | | Distal duct | 69 | 31 (44.9) | | | 34 (49.3) | | | Bile stone | | | | | | | | No | 69 | 33 (47.8) | 3.101 | 0.078 | 36 (52.2) | 2.392 | 0.122 | Yes | 31 | 9 (29.0) | | | 11 (35.5) | | | Lymphnode metastasis | | | | | | | | No | 62 | 38 (61.3) | 24.924 | 0.000 | 39 (62.9) | 16.566 | 0.000 | Yes | 38 | 4 (10.5) | 8 (21.1) | Invasion | | | | | | | | No | 33 | 22 (66.7) | 12.320 | 0.000 | 22 (66.7) | 7.648 | 0.006 | Yes | 67 | 20 (29.2) | 25 (37.3) | TNM stage | | | | | | | | I+II | 35 | 23 (65.7) | 21.460 | 0.000 | 26 (74.3) | 27.598 | 0.000 | III | 38 | 17 (44.7) | | | 19 (50.0) | | | IV | 27 | 2 (7.4) | | | 2 (7.4) | | | Surgery | | | | | | | | Radical | 54 | 32 (59.3) | 15.078 | 0.001 | 36 (66.7) | 19.220 | 0.000 | Palliative | 36 | 9 (25.0) | | | 10 (27.8) | | | Biopsy | 10 | 1 (10.0) | | | 1 (80.0) | | |
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DSG1: desmoglein 1; DSG2: desmoglein 2; EHCC: extrahepatic cholangiocarcinoma; Pos No.: positive number.
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