Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma

Table 5

Multivariate Cox regression analysis of survival rate in patients with EHCC and DSG1 and DSG2 expression.

Groups	Factors		SE	Wald		RR	95% CI
							Lower	Upper
Differentiated degree	Well/moderately/poorly	0.526	0.158	11.083	0.001	1.692	1.241	2.306
Tumour size	≤3 cm/>3 cm	0.515	0.240	4.605	0.032	1.674	1.046	2.679
Lymph node metastasis	No/yes	0.744	0.319	5.440	0.020	2.104	1.126	3.932
Invasion	No/yes	0.785	0.327	5.763	0.016	2.192	1.155	4.162
TNM stage	I/II/III/IV	0.829	0.276	9.022	0.003	2.291	1.334	3.935
Surgery	Radical/palliative/biopsy	0.398	0.191	4.342	0.037	1.498	1.024	2.165
DSG1	−/+	-0.728	0.331	4.837	0.028	0.483	0.252	0.924
DSG2	−/+	-0.672	0.329	4.172	0.041	0.511	0.268	0.973

−: negative expression; +: positive expression; RR: relative risk; CI: confidence interval.