Research Article
Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
Table 2
Nuclear morphological characteristics of the invasive breast cancer with three groups.
| Characteristics | Cases | value | | HR+/HER2- | HR-/HER2+ | HR-/HER2- | HR+/HER2- vs. HR-/HER2+ | HR+/HER2- vs. HR-/HER2- | HR-/HER2+ vs. HR-/HER2- |
| Nuclear/cytoplasmic ratio | | | | 0.317 | 0.610 | 1.000 | ≤1 | 82 | 51 | 22 | | | | > 1 | 4 | 5 | 2 | | | | Difference of nuclear size | | | | <0.001 | 0.068 | 0.033 | | 84 | 35 | 21 | | | | | 2 | 21 | 3 | | | | Nuclear pleomorphism | | | | <0.001 | 0.218 | 0.267 | Mild-moderate | 86 | 47 | 23 | | | | Severe | 0 | 9 | 1 | | | | Chromatin feature | | | | 0.202 | 0.558 | 0.781 | Fine-powder | 82 | 42 | 19 | | | | Granular | 4 | 14 | 5 | | | | Nuclear membrane | | | | 0.314 | 1.000 | 0.523 | Absent or few | 21 | 18 | 6 | | | | Conspicuous | 65 | 38 | 18 | | | | Nucleoli | | | | <0.001 | 0.053 | 0.189 | Absent or few | 33 | 3 | 4 | | | | Conspicuous | 53 | 53 | 20 | | | | Nucleolar size | | | | <0.001 | <0.001 | 0.373 | Micro | 44 | 9 | 2 | | | | Medium | 9 | 36 | 12 | | | | Large | 0 | 8 | 6 | | | | Nucleolar number | | | | <0.001 | <0.001 | 1.000 | 1 | 16 | 49 | 19 | | | | 2 | 18 | 4 | 1 | | | | ≥ 3 | 19 | 0 | 0 | | | | Histological grade | | | | <0.001 | 0.019 | <0.001 | I | 19 | 0 | 0 | | | | II | 59 | 30 | 22 | | | | III | 8 | 26 | 2 | | | | Tubule formation | | | | 0.075 | <0.001 | 0.090 | 1 | 5 | 0 | 0 | | | | 2 | 19 | 19 | 13 | | | | 3 | 62 | 37 | 11 | | | | Pleomorphism | | | | <0.001 | <0.001 | <0.001 | 1 | 28 | 0 | 0 | | | | 2 | 54 | 20 | 20 | | | | 3 | 4 | 36 | 4 | | | | Mitotic counts | | | | <0.001 | 0.004 | 0.668 | 1 | 23 | 0 | 0 | | | | 2 | 57 | 50 | 23 | | | | 3 | 6 | 6 | 1 | | | |
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Nucleolar size: micro (average μm), medium ( ), and large (average μm). |