Research Article
Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2
Table 3
Nuclear morphological characteristics of the invasive breast cancer with Ki-67 expression.
| Characteristics | HR+/HER2- | HR-/HER2+ | All cases | | | | value | | | value | | | value |
| | (39.5%) | (60.5%) | | (8.9%) | (91.1%) | | (27.5%) | (72.5%) | | Nuclear/cytoplasmic ratio | | | 1.000 | | | 1.000 | | | 0.444 | ≤1 | 33 | 49 | | 5 | 46 | | 38 | 95 | | > 1 | 1 | 3 | | 0 | 5 | | 1 | 8 | | Difference of nuclear size | | | 1.000 | | | 1.000 | | | 0.126 | | 33 | 51 | | 3 | 32 | | 36 | 83 | | | 1 | 1 | | 2 | 19 | | 3 | 20 | | Nuclear pleomorphism | | | 1.000 | | | 0.580 | | | 0.064 | Mild-moderate | 34 | 48 | | 5 | 46 | | 39 | 94 | | Severe | 0 | 4 | | 0 | 5 | | 0 | 9 | | Chromatin feature | | | 1.000 | | | 0.316 | | | 0.244 | Fine-powder | 29 | 43 | | 5 | 37 | | 34 | 80 | | Granular | 5 | 9 | | 0 | 14 | | 5 | 23 | | Nuclear membrane | | | 0.504 | | | 0.652 | | | 0.533 | Absent or few | 7 | 14 | | 2 | 16 | | 9 | 30 | | Conspicuous | 27 | 38 | | 3 | 35 | | 30 | 73 | | Nucleoli | | | 0.635 | | | 0.249 | | | 0.179 | Absent or little | 12 | 21 | | 1 | 2 | | 13 | 23 | | Conspicuous | 22 | 31 | | 4 | 49 | | 26 | 80 | | Nucleolar size | | | 0.064 | | | 1.000 | | | <0.001 | Micro | 21 | 22 | | 1 | 8 | | 22 | 30 | | Medium | 2 | 8 | | 3 | 33 | | 5 | 41 | | Large | 0 | 0 | | 0 | 8 | | 0 | 8 | | Nucleolar number | | | 0.632 | | | 1.000 | | | 0.003 | 1 | 4 | 9 | | 4 | 44 | | 8 | 53 | | 2 | 6 | 9 | | 0 | 4 | | 6 | 13 | | ≥ 3 | 12 | 13 | | 0 | 1 | | 12 | 14 | | Histological grade | | | 0.365 | | | 0.172 | | | 0.022 | I | 10 | 9 | | 0 | 0 | | 10 | 9 | | II | 22 | 37 | | 1 | 29 | | 23 | 66 | | III | 2 | 6 | | 4 | 22 | | 6 | 28 | | Tubule formation | | | 0.590 | | | 0.155 | | | 0.174 | 1 | 3 | 2 | | 0 | 0 | | 3 | 2 | | 2 | 8 | 11 | | 0 | 19 | | 8 | 30 | | 3 | 23 | 39 | | 5 | 32 | | 28 | 71 | | Pleomorphism | | | 0.462 | | | 0.645 | | | 0.003 | 1 | 14 | 14 | | 0 | 0 | | 14 | 14 | | 2 | 19 | 35 | | 1 | 19 | | 20 | 54 | | 3 | 1 | 3 | | 4 | 32 | | 5 | 35 | | Mitotic counts | | | 0.449 | | | 1.000 | | | 0.255 | 1 | 8 | 15 | | 0 | 0 | | 8 | 15 | | 2 | 25 | 32 | | 5 | 45 | | 30 | 77 | | 3 | 1 | 5 | | 0 | 6 | | 1 | 11 | |
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