Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2

Table 3

Nuclear morphological characteristics of the invasive breast cancer with Ki-67 expression.

Characteristics	HR+/HER2-			HR-/HER2+			All cases
			value			value			value
	(39.5%)	(60.5%)		(8.9%)	(91.1%)		(27.5%)	(72.5%)
Nuclear/cytoplasmic ratio			1.000			1.000			0.444
≤1	33	49		5	46		38	95
> 1	1	3		0	5		1	8
Difference of nuclear size			1.000			1.000			0.126
	33	51		3	32		36	83
	1	1		2	19		3	20
Nuclear pleomorphism			1.000			0.580			0.064
Mild-moderate	34	48		5	46		39	94
Severe	0	4		0	5		0	9
Chromatin feature			1.000			0.316			0.244
Fine-powder	29	43		5	37		34	80
Granular	5	9		0	14		5	23
Nuclear membrane			0.504			0.652			0.533
Absent or few	7	14		2	16		9	30
Conspicuous	27	38		3	35		30	73
Nucleoli			0.635			0.249			0.179
Absent or little	12	21		1	2		13	23
Conspicuous	22	31		4	49		26	80
Nucleolar size			0.064			1.000			<0.001
Micro	21	22		1	8		22	30
Medium	2	8		3	33		5	41
Large	0	0		0	8		0	8
Nucleolar number			0.632			1.000			0.003
1	4	9		4	44		8	53
2	6	9		0	4		6	13
≥ 3	12	13		0	1		12	14
Histological grade			0.365			0.172			0.022
I	10	9		0	0		10	9
II	22	37		1	29		23	66
III	2	6		4	22		6	28
Tubule formation			0.590			0.155			0.174
1	3	2		0	0		3	2
2	8	11		0	19		8	30
3	23	39		5	32		28	71
Pleomorphism			0.462			0.645			0.003
1	14	14		0	0		14	14
2	19	35		1	19		20	54
3	1	3		4	32		5	35
Mitotic counts			0.449			1.000			0.255
1	8	15		0	0		8	15
2	25	32		5	45		30	77
3	1	5		0	6		1	11