The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials

Table 1

Immune/inflammatory factors and their influential effects on EZH2.

Immune/inflammatory factor	Effect of factors on EZH2 at a tumor milieu	Citations
Nutrients	Inhibitory	74
Hypoxia	Inhibitory	74
Acidic stress	Inhibitory	74
AXL	Inhibitory	53
n-Butylidenephthalide	Inhibitory	71
STAT3	Inhibitory	64, 79
INK4B-ARF-INK4A	Inhibitory	69, 80, 81
p57	Inhibitory	69, 80, 81
BMPR1B	Inhibitory	69, 80, 81
MyoD	Inhibitory	69, 80, 81
RUNX3	Inhibitory	69, 80, 81
CHD1	Inhibitory	82
TRAIL	Inhibitory	83, 84
FBO32	Inhibitory	83, 84
Vasohibin1	Inhibitory	85
MICU1	Inhibitory	86
Oxygen (O2)	Facilitatory	69
Deoxyglucose	Facilitatory	69
HIF1α	Facilitatory	69
PHD1-3	Facilitatory	69
EAF2	Inhibitory	69
siRNA	Inhibitory	87
DZNep	Inhibitory	87
GSK343	Inhibitory	31
CDKN2A	Inhibitory	12, 93
BRAF V600E	Facilitatory	93
iNOS	Inhibitory	94
TNF-α	Inhibitory	94
HCMV	Facilitatory	95
BMI1	Facilitatory	74