Anlotinib Suppresses Oral Squamous Cell Carcinoma Growth and Metastasis by Targeting the RAS Protein to Inhibit the PI3K/Akt Signalling Pathway

<div>Effect of anlotinib on the RAS and PI3K/Akt signalling pathways in HSC-3 cells. HSC-3 cells were treated with anlotinib for 72 hours. Total RAS, phosphorylated and total Akt, and <i>β</i>-actin were detected by western blotting. (a) Molecular mechanism of anlotinib in HSC-3 cell apoptosis. (b) Changes in the p-Akt/Akt ratio in apoptosis. (c) Ratio changes of RAS, PI3K, and Bad proteins in apoptosis based on quantitative results of protein expression. 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Analytical Cellular Pathology

fig6

Figure 6

Figure 6: Anlotinib Suppresses Oral Squamous Cell Carcinoma Growth and Metastasis by Targeting the RAS Protein to Inhibit the PI3K/Akt Signalling Pathway 

Figure 6 | Anlotinib Suppresses Oral Squamous Cell Carcinoma Growth and Metastasis by Targeting the RAS Protein to Inhibit the PI3K/Akt Signalling Pathway 