Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway

Figure 4

Effect of shikonin on survivin. (a) Docked molecule (shikonin) in the crystal structure of survivin (PDB ID: 1XOX). Hydrogen bonds were depicted as dashed yellow lines. (b) The mRNA level of survivin in H1299 cells treated with shikonin (0, 0.78, 1.56, and 3.12 μM) for 48 h. (c) The protein level of survivin in H1299 cells treated with shikonin (0, 0.78, 1.56, and 3.12 μM) for 48 h was examined by western blot assay. Data are presented as the (). and vs. control.

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