Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway

Figure 5

Effect of shikonin on molecules of cell apoptosis and cycle-related signaling. (a) Protein levels of XIAP and cleaved caspases 3 and 9 in H1299 cells treated with shikonin (0, 0.78, 1.56, and 3.12 μM) for 48 h were examined by western blot assay. (b) The protein levels of CDK2, CDK4, cyclin E, and cyclin D1 in H1299 cells treated with shikonin (0, 0.78, 1.56, and 3.12 μM) for 48 h were examined by western blot assay. Data are presented as the (). , , and vs. control.

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