Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29

Figure 6

Flow chart. HI models were established successfully. The upregulated IL-10 expression and cell swelling which lead to organs (bilateral cortex, bilateral hippocampus, and lung tissues) damage are induced by HI. IL-10 is coexpressed in neurons and astrocytes, and its elevation promoted the recovery of injured tissues. Importantly, the expression of Bcl-2 and ERp29 was downregulated following IL-10 mRNA silence, indicating that IL-10 exerts its antiapoptosis and neuroprotective function through regulating Bcl-2 and ERp29.