Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

Table 1

Eight different types of ABPs and their family members.

Types	Members	Ref.
Actin monomer-binding proteins	Profilin family, vitamin D binding protein, anillin, transgelin, twinfilin, thymosin-β4, WASp-homology 2, cofilin family, etc.	[3, 149]
Severing proteins	Cofilin family, gelsolin family, destrin, villin, depactin, actophorin, etc.	[3, 121]
Nucleation proteins	Arp2/3 complex, formins, spire, cordon bleu, leiomodin, etc.	[3, 150, 151]
Actin filament polymerases	ENA/vasodilator-stimulated phosphoprotein, profifilin, mDia1, etc.	[3, 152]
Capping proteins	Tropomodulin, heterodimeric capping protein, Arp2/3 complex, barbed-end capping proteins, fragmin, severin, gelsolin, villin, V-1/myotrophin, sequesters, gelsolin family, coronin-like 1C, muscle Z-line alpha subunit 1, etc.	[3, 71, 97, 149, 153–156]
Cross-linking proteins	Fimbrin, α-actinin family, fodrin, actinogelin, caldesmon, gelactin family, mapping filamin, fascin, actin-binding domains, EF hand proteins, calcium-binding motif, paxillin, etc.	[3, 149, 157, 158]
Filament-binding proteins	Tropomyosin, myosins, synapsin, spectrin, troponin, vinculin, metavinculin, actin filament-associated protein, girdin, SWAP70, synaptopodin, PDZ and LIM domain protein 4, etc.	[111, 149, 159–161]
Bundling proteins	Fascin, fimbrin, villin, erythrocyte membrane protein band 4.9, etc.	[159, 162–164]