Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

Table 2

Some ABPs are involved in different immune-inflammation diseases.

ABP	Diseases involved	Effects on the inflammatory environment	Ref.
Gelsolin	Myelination and remyelination of the peripheral nervous system (PsA)	Inhibits migration of macrophages and clears macrophages; Shows a negative correlation between C-reactive protein and erythrocyte sedimentation rate	[68, 70]
Tβ4	Liver injury and lung injury inflammation	Blocks the production of proinflammatory cytokines; Proinflammatory response	[71, 73]
Profilin-1	Lung injury inflammation	Proinflammatory response	[73]
Filamin	Inflammatory state of melanoma cells	Inhibits TNF, IL-1, toll receptor, and TRAF2-induced NF-κB activation	[74–76]
Villin-1	Gastrointestinal inflammation	Increased expression of villin-1 inhibits gastrointestinal inflammation; Regulates immunogenic IEC death	[77]
SYNPO	Inflammatory bowel diseases	Regulates intestinal mucosal susceptibility and permeability	[78]
Cortactin	Inflammation in the cremaster muscle; Neural inflammation	Regulates actomyosin contractility and leukocyte transendothelial migration; Supports leukocyte transmigration	[79, 80]