Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts

Figure 3

Tumors in different groups on CEUS. (a) An intense enhancement was shown in the tumor on CEUS (red circle) in the M group, and the tumor was heterogeneous hypoechoic on 2DUS and sized (white arrow), with the PI of 25.1 (10-5 AU) and the AUC of 858.9 (10-5 AU·s) on TIC. (b) A heterogeneous enhancement with spotty filling defect was shown in the tumor on CEUS (red circle) in the UTMD group, and the tumor was heterogeneous hypoechoic on 2DUS and sized (white arrow), with the PI of 22.5 (10-5 AU) and the AUC of 724.3 (10-5 AU·s) on TIC. (c) The heterogeneous enhancement with patchy filling defect was noted in the tumor on CEUS (red circle) in the APA group, and the tumor was homogeneous hypoechoic on 2DUS and sized (white arrow), with the PI value of 11.6 (10-5 AU) and the AUC of 589.9 (10-5 AU·s) on TIC. (d) The heterogeneous enhancement with patchy filling defect and homogeneous hypoechoicity was observed in the tumor on CEUS (red circle) in the APA-U group, and the tumor had homogeneous hypoechoicity on 2DUS and a small size (; white arrow), with the PI of 8.0 (10-5 AU) and the AUC of 372.1 (10-5 AU·s) on TIC.

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