Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts

Figure 4

Immunohistochemistry for VEGF in different groups (×400). (a) A large number of brown granules were diffusely distributed in the cytoplasm of tumor cells in the M group, and the VEGF IOD was 8629.55. (b) A large number of brown granules were diffusely distributed in the cytoplasm of tumor cells in the UTMD group, and the VEGF IOD was 8045.29. (c) In the APA group, the brown flaky granules were distributed in the cytoplasm of tumor cells, and the VEGF IOD was 6986.39. (d) In the APA-U group, the brown granules were scattered in the cytoplasm of tumor cells, and the VEGF IOD was 5276.10.

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