Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer

Figure 1

Mechanism of action of radiotherapy and development of radioresistance. (a) (1) Mechanisms of action of radiotherapy. The principle of RT is classified into two types according to different injury mechanisms: direct effect and indirect effect. (2). DNA damage: double-strand break, single-strand break, and nucleotide base damage. (b) Major mechanisms of radioresistance: (1) regulating the cell cycle, (2) repairing the damaged DNAs, (3) escaping from apoptosis, and (4) generating the CSCs.