Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms

Figure 5

T-96-induced antitumor effects in mice. (a–d) T-96 inhibited SUM1315 cell proliferation in vivo; (e), T-96 induced SUM-1315 cells apoptosis by TUNEL; (f), T-96 decreased Ki-67 protein expression in SUM-1315 cells by immunofluorescence assay; (g and h) T-96 increased histone methylation by immunohistochemical assay; (i), T-96 increased PTEN protein expression in SUM-1315 cell by immunohistochemical assay. Values are statistically significant at .

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