“Derived Multiple Allogeneic Protein Paracrine Signaling (d-MAPPS)” Enhances T Cell-Driven Immune Response to Murine Mammary Carcinoma

Figure 5

d-MAPPS increased antitumorigenic CD4+ Th1 and Th17 cells and decreased immunosuppressive T regulatory cells in the tumors of 4T1-treated mice. Total number of (a) IFN-γ-producing CD4+ Th1 cells, (b) IL-17-producing CD4+ Th17 cells, (c) IL-4-producing CD4+ Th2 cells, (d) IL-10-producing CD4+ T cells, and (e) FoxP3-expressing CD4+ Tregs in the tumors of 4T1+saline-treated (black bars) and 4T1+d-MAPPS-treated mice (white bars), as determined by the flow cytometry analysis and intracellular staining of tumor-infiltrated mononuclear cells. Data are presented as ( mice/group; ; ).

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