Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy

<div>Growth-inhibitory effect of MK2206 2HCl on OSCC cell lines. (a) MK2206 2HCl treatment inhibited CAL27 cell proliferation, determined by MTT assay. (b) MK2206 2HCl treatment inhibited SCC25 cell proliferation, determined by MTT assay. (c) Colony formation assay showed that MK2206 2HCl inhibited colony formation of CAL27 cells. (d) The colony formation assay showed that MK2206 2HCl inhibited colony formation of SCC25 cells. 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Analytical Cellular Pathology

fig6

Figure 6

Figure 6: Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy 