Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy

<div>MK2206 2HCl induces cell cycle arrest at G2/M in OSCC cell lines. (a) MK2206 2HCl induces cell cycle arrest at G2/M in CAL27 cells. (b) MK2206 2HCl induces cell cycle arrest at G2/M in SCC25 cells. (c) MK2206 2HCl increased the protein expression of p21 and inhibited p-Rb expression by western blotting in CAL27 and SCC25 cells. 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Analytical Cellular Pathology

fig7

Figure 7

Figure 7: Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy 