Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer

<div>Effect of anlotinib combined with 5-FU in SCLC cell lines. The H446, H1688, and H187 cells were treated with anlotinib, 5-FU, or combination of both for 72 h, and cell growth was detected using CCK8 kit. The inhibition rates in the (a) H446 cells, (b) H1688 cells, and (c) H187 cells following treatment with anlotinib and 5-FU in different drug concentrations (0 <i>μ</i>M, 0.01 <i>μ</i>M, 0.1 <i>μ</i>M, 1 <i>μ</i>M, 10 <i>μ</i>M, and 20 <i>μ</i>M) while 5-FU remained a fixed concentration in the mixture. 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SCLC: small-cell-lung cancer.</div>

Analytical Cellular Pathology

fig1

Figure 1

Figure 1: Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer 

Figure 1 | Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer 